Artisanal Nutraceutical Cognitive Wellness, Research-Founded
Every formula defensible by published evidence. Every ingredient at dosages research actually supports. Built by mycologist Leandro Manosso through years of cognitive neuroscience study.
Three cognitive mushroom formulations, each verified by DNA testing and standardized to research-supported compounds.
Fruiting body extract using hot water and alcohol dual extraction to capture both polysaccharides (beta-glucans) and terpenoid compounds (hericenones and erinacines). Standardized to 30% beta-glucan content. Species verified by DNA testing for authentic Hericium erinaceus identification.
Lion's mane (400mg), cordyceps militaris (300mg), and reishi (200mg). Three functional mushrooms with distinct published research profiles. All fruiting body extracts, not mycelium-on-grain. Dual-extracted for complete compound capture. Each mushroom contributes different bioactive compounds backed by human studies.
Lion's mane extract (500mg) combined with bacopa monnieri (300mg standardized to 50% bacosides). A mushroom-botanical combination addressing cognitive nutrition through two distinct mechanisms. Published human studies exist for both compounds individually at these dosages.
Founder & Research Mycologist
After years researching published cognitive neuroscience literature, Leandro founded Manosso around one principle: every formula must be defensible by published evidence, every ingredient at a dosage the research actually supports.
Manosso exists because most supplement companies ignore dosage science. They use trace amounts that look good on labels but have no research backing. We do the opposite: study the literature, find the effective dosages, then formulate exactly to those specifications.
Every Manosso formula begins with published human studies. We identify the specific dosages and extraction methods that produced measurable results in research settings. Then we source those exact specifications. No shortcuts, no marketing doses.
What the research reveals about functional mushrooms and cognitive wellness.
Hericium erinaceus contains hericenones and erinacines, compounds that cross the blood-brain barrier and stimulate nerve growth factor (NGF) synthesis. Published human studies show cognitive improvements in older adults at 500mg-1000mg daily dosages of fruiting body extract.
Bacopa monnieri standardized to 50% bacosides shows memory enhancement in multiple human trials. The bacosides work through different pathways than mushroom compounds, creating complementary cognitive support mechanisms when combined appropriately.
Single-extraction methods miss bioactive compounds. Hot water extracts beta-glucans but leaves terpenoids behind. Alcohol extracts capture terpenoids but misses water-soluble compounds. Dual extraction captures both fractions for complete profiles.
Most supplements contain 100-200mg mushroom extracts that look impressive but fall short of research-effective dosages. Effective lion's mane studies use 500mg-1000mg daily. We formulate to research specifications, not marketing convenience.
How we ensure what you receive matches published research specifications.
Every mushroom lot undergoes DNA sequencing to confirm species identity. Prevents substitution with cheaper or ineffective mushroom species commonly found in the supplement industry.
HPLC testing verifies bioactive compound concentrations match our standardization targets. Third-party laboratories confirm beta-glucan content, bacoside percentages, and absence of contaminants.
Complete documentation from cultivation through extraction to encapsulation. Every batch traceable to source cultivators who follow our fruiting body specifications.
Time-course analysis ensures bioactive compounds remain stable throughout shelf life. Proper storage conditions maintained from processing through delivery to preserve research-level potency.
Published research uses fruiting body extracts, not mycelium-on-grain. Fruiting bodies contain the actual compounds studied in human trials. Mycelium-on-grain often contains more grain starch than mushroom compounds. More expensive, but scientifically accurate.
We use the exact dosages that produced results in published studies. Our 500mg lion's mane matches successful research protocols. Most brands use 100-200mg trace amounts that look good on labels but have no research backing.
DNA testing confirms species before processing. The supplement industry has widespread species substitution issues. We verify each lot contains authentic Hericium erinaceus, Ganoderma lucidum, and Cordyceps militaris through genetic sequencing.
Dual extraction: hot water captures polysaccharides (beta-glucans), alcohol captures terpenoids (hericenones, erinacines). Single extractions miss bioactive compounds. We combine both fractions for complete profiles matching research specifications.
Follow research protocols: lion's mane shows best results with consistent daily use over 8-12 weeks. Take with food for optimal absorption. Bacopa combinations work best when taken consistently at the same time daily. Individual responses vary.
Manosso operates from Ponta Grossa, Paraná, Brazil as Leandro Manosso Andrade LTDA. Our location provides access to certified extraction facilities and direct cultivator relationships. All processing follows research-grade specifications.
Get notifications about new formulations and research findings. Mycology insights and product availability updates.
The scientific foundation behind every Manosso formulation.
Every ingredient must have published human trials showing efficacy at our dosages. We reject compounds with only animal studies or in vitro research. Real cognitive benefits require real human data.
Each milligram justified by published research. Lion's mane at 500mg matches successful cognitive studies. Bacopa at 300mg (standardized to 50% bacosides) follows memory enhancement protocols. No arbitrary or marketing-driven dosages.
Our dual extraction methods replicate those used in successful research studies. Hot water and alcohol extractions combined to capture the full spectrum of bioactive compounds that produced measurable results in human trials.
Continuous monitoring of new research publications. When new studies emerge with better dosing protocols or extraction methods, we evaluate reformulations. Science evolves, and formulations should too.